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Synthesis of blood group Forssman pentasaccharide GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ–R

Mendeleev Communication – https://doi.org/10.1016/j.mencom.2019.09.034

Summary: Synthesis of Forssman glycolipid FSL-FS-5. Kodeyctes and native FORS1+ donor used to compare reactivity toward monoclonal anti-Forssman antibody

Inna S. Popova,Elena Yu. Korchagina, Marina A. Sablina, Alexander S. Paramonov, Annika K. Hult, Stephen M. Henry and Nicolai V. Bovin, Mendeleev Commun., (2019) 29, 578-580

Synthesis of the glycan part of Forssman glycolipid GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc–Cer in the form of 2-aminoethyl glycoside has been carried out. The glycoside has been converted into a lipophilic derivative capable of controlled inserting into erythrocytes. The obtained surface-modified cells, termed kodecytes, revealed a high level of the blood group system FORS serological activity.

Graphical abstract