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Synthetic glycolipid-like constructs as tools for glycobiology research, diagnostics, and as potential therapeutics

Biochemistry (Moscow) – https://doi.org/10.1134/S0006297915070068 Summary: Review of Function-Spacer-Lipid Contructs. Korchagina, Elena and Stephen Henry. “Synthetic glycolipid-like constructs as tools for glycobiology research, diagnostics, and as potential therapeutics.” Biochemistry (Moscow) (2015); 80(7): 857-871. Abstract Function—spacer—lipid (FSL) constructs are amphiphilic molecules that are able to disperse in water and then self-assemble into… Read More »Synthetic glycolipid-like constructs as tools for glycobiology research, diagnostics, and as potential therapeutics

Training students in serologic reaction grading increased perceptions of self‐efficacy and ability to recognize serologic reactions but decreased grading accuracy

Transfusion Journal Open Access – https://doi.org/10.1111/trf.12985 Summary: The use of serologic grading panels created with kodecytes was suitable as a tool to recognize and monitor serologic grading abilities. Evidence suggests that for both students and practitioners to gain and sustain competency in serologic reaction recognition and grading, they will require… Read More »Training students in serologic reaction grading increased perceptions of self‐efficacy and ability to recognize serologic reactions but decreased grading accuracy

Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids

Virologica Sinica – https://www.virosin.org/fileup/PDF/20140401.pdf Summary: Here we describe an alternative approach of influenza virus labeling that utilizes Function-Spacer-Lipid (FSL) constructs that can be gently inserted into the virus membrane. Ilyushina, Natalia A., et al. “Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids.” VIROLOGICA SINICA (2014); 29(4): 199-210. Direct… Read More »Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids

Monoclonal anti‐A activity against the FORS1 (Forssman) antigen

Transfusion Journal Open Access – https://doi.org/10.1111/trf.12661 Summary: In the absence of natural FORS1-positive red blood cells (RBCs), kodecytes were created with synthetic disaccharide and pentasaccharide Forssman function-spacer-lipid (FSL) constructs, Fsdi-kodecytes, and FORS1-kodecytes, respectively. FSL constructs were also applied to solid surfaces and used in solid-phase enzyme immunoassays. Barr, Katie, Elena… Read More »Monoclonal anti‐A activity against the FORS1 (Forssman) antigen

Mapping the fine specificity of ABO monoclonal reagents with A and B type‐specific function‐spacer‐lipid constructs in kodecytes and inkjet printed on paper

Transfusion Journal Open Access – https://doi.org/10.1111/trf.12661 Mapping of MoAbs with kodecytes and printed FSL constructs revealed a series of broad recognition patterns. All ABO MoAbs tested were reactive with the RBC dominant Type 2 ABO antigens. Unexpectedly some anti-A reagents were reactive against the B Type 1 antigen, while others… Read More »Mapping the fine specificity of ABO monoclonal reagents with A and B type‐specific function‐spacer‐lipid constructs in kodecytes and inkjet printed on paper

Forssman expression on human erythrocytes: biochemical and genetic evidence of a new histo-blood group system

Blood – https://doi.org/10.1182/blood-2012-10-455055 Summary: A new histo-blood group system was discovered, based on the identification of Forssman glycolipid antigen on human red blood cells. A newly described polymorphism in the GBGT1 gene activates the encoded enzyme to synthesize Forssman antigen. Svensson, Lola,. Annika K. Hult, Robert Stamps, Jonas Ångström, Susann… Read More »Forssman expression on human erythrocytes: biochemical and genetic evidence of a new histo-blood group system

PEGylation of Vesicular Stomatitis Virus Extends Virus Persistence in Blood Circulation of Passively Immunized Mice

Journal of Virology – https://jvi.asm.org/content/87/7/3752.short Summary: Mayo Clinic used FSL-PEG constructs to extend the circulatory life of virus Tesfay MZ, Krik A, Hadac EM, Griesmann GE, Federspiel MJ, Barber GN, Henry SM, Peng K-W, Russell SJ. PEGylation of Vesicular Stomatitis Virus Extends Virus Persistence in Blood Circulation of Passively Immunized… Read More »PEGylation of Vesicular Stomatitis Virus Extends Virus Persistence in Blood Circulation of Passively Immunized Mice

Toward creating cell membrane glyco-landscapes with glycan lipid constructs

Carbohydrate Research – https://doi.org/10.1016/j.carres.2012.03.044 Summary: Review of synthesis of FSL constructs and most applications related to sugars Korchagina E, Tuzikov A, Formanovsky A, Popova I, Henry S, and Bovin N. Toward creating cell membrane glycolandscapes with glycan lipid constructs. Carbohydrate Research (2012); 356: 238-246 Abstract Synthetic glycolipid-like constructs dispersible in… Read More »Toward creating cell membrane glyco-landscapes with glycan lipid constructs

Modeling transfusion reactions with kodecytes and enabling ABO‐incompatible transfusion with function‐spacer‐lipid constructs

ISBT Science Series Open Access – https://doi.org/10.1111/j.1751-2824.2012.01563.x Summary: Review on use of FSLs to neutralise circulating ABO antibodies and allow incompatible transfusion (in mouse model). Also shows inkjet printing antibody assay Henry S, Barr K, Oliver C. Modeling transfusion reactions with kodecytes and enabling ABO-incompatible transfusion with Function-Spacer-Lipid constructs. ISBT… Read More »Modeling transfusion reactions with kodecytes and enabling ABO‐incompatible transfusion with function‐spacer‐lipid constructs